Small Animal Image Guided Irradiation System

Precision X-Ray, PXi, X-RAD 225 Cx, image-guided placement of irradiation distributions within pre-clinical subjects, XRAD SmART


Advancing our understanding of the molecular biology of cancer requires more precise tools to study the radiation induced effects used in translational research.

Five years ago, Precision X-Ray introduced the X-RAD 225Cx, which showed that combining 3D volumetric imaging with highly accurate specimen positioning allowed for precise, conformal image-guided radiation therapy to specific targets in mice, rats and rabbits. The X-RAD SmART, the next generation of cabinet IGRT systems, takes this to a new level of precision.

The X-RAD SmART takes the already excellent design of the X-RAD 225Cx, and improves it in every way imaginable. The redesigned cabinet still provides complete shielding from all internal x-rays, while moving to a more flexible design, allowing for installations in just about any laboratory space. The new cabinet design is not just about increased efficiency, however, as it also has higher precision electromechanics under the hood, allowing for even better targeting accuracy.

Superior hardware, however, cannot be fully taken advantage of without superior software. Pilot, developed by the esteemed scientific team at Princess Margaret Cancer Center, is a fully functional suite of tools used to acquire images, deliver therapy, guide the targeting system and control system calibrations. SmART Plan, developed at Maastro Clinic, combines a user friendly interface with state-of-the-art Monte Carlo calculation algorithms to rapidly devise treatment plans with gold standard accuracy for static beams, arcs, and even non-coplanar treatments across single and multiple isocenters. This enables rapid, accurate treatments to be delivered in any scenario, ranging from simple subcutaneous xenografts all the way to complex metastatic models.

However, the system is not limited to CT guidance alone. The X-RAD SmART is the ONLY system with a fully integrated Bioluminescence Imaging Platform. Because the system is fully integrated, registration with CT is fully automated, allowing for precise tumor localization for non-palpable tumors. The system can also serve to measure tumor viability across studies. As well, Co-Pilot, developed by the Netherlands Cancer Institute can automatically register DICOM images from other available platforms, effectively providing multi-modality image-guidance.

These features, combined with PXI’s legendary service, make the X-RAD SmART the clear choice in small animal precision radiotherapy


Irradiation Performance

Irradiation Energy: 10-225 kVp, 3000 Watts (4500 Watts optional)
Dose Rate: 1- >600 cGy/min (depending on X-ray settings, beam filtration and collimation)
Beam Filtration: User Interchangeable Slides, 2 HVL’s provided (2.0mm Al & 0.3mm Cu), others optional
Collimation: Conformal Collimators available in sizes from 1mm to 10cm in round, rectangular, and custom shapes
Beam Orientation: Static or Dynamic 0-360 degrees
Isocenter Distance: 30 cm typical
Image Guided Targeting Precision: Up to 0.1mm

CT Imaging Performance

Volumetric Imaging Resolution: 0.1mm (nominal)
Volumetric Field of View: 10cm x 10cm without moving specimen couch
Acquisition Time: Volume dependent, 60 seconds typical
Imaging Dose: <10 cGy/min (typical)

System Components

X-ray Production:
X-ray Power Supply: GE ISOVOLT 225kV, 4.5kW, Constant Potential, Continuous Duty

X-ray Tube:
Comet (640/4500 W) Focal Spot: d=0.4mm/ d=3.0mm
Thales (900/4000 W) Focal Spot: d=0.4mm/ d=3.0mm (option)

X-ray Cooling System:
Closed Loop, Water to Air Heat Exchanger, 4000 Watt Dissipation

Imaging Detector Panel:
Detector Type: aSi array using a CsI (TI) scintillator
Pixel Size: 200 µm
Image Size: 1024 x 1024
Frame Rate: 15 Hz

Optical Camera:
EMCCD Sensor
9.7 cm FOV at imaging isocenter
0.2 mm resolution
Filter Wheel for support of multiple wavelength acquisition
Fully Integrated Inside Cabinet for easy registration with CT imaging

Optical Imaging Performance:
Camera Resolution: 0.2 mm
Filters Available: 562 nm, 591 nm, 624 nm, 655 nm
CT Registration Accuracy: 0.2 mm
Optical Targeting Accuracy: <1 mm

Imaging Panel

Perkin Elmer XRD 0820 AN3-ES
Active pixels: (1024 x 1024)
Pitch: 200µm
Total Area: 20 cm x 20 cm
Capture Speed: 15 fps (30 fps with 2x2 binning)

Application Software

Pilot® Image acquisition and reconstruction, 3D alignment and targeting software package (licensed by Princess Margaret Cancer Center in Toronto, Canada)
Co-Pilot Registration Software for Multi-Modality Image-Guidance
Windows© 64 Bit OS with remote diagnostics and support capability
Database Management Tools enable quick management of images, treatments, and studies by each researcher
DICOM importable and exportable image data
SmART Plan Treatment Planning System featuring state-of-the-art Monte Carlo Calculation Algorithms

Motion Stages

Rotational Gantry: 360 degrees, 0-3 RPM, 6 arc minute repeatability
X-Y-Z Animal Stage: ±10cm travel in X & Y, ±15cm in Z (vertical), 36mm/sec (adjustable), ±32 micron repeatability

Cabinet Dimensions and Weight

76.5”h x 60”w x 41”d (196cm h x 154cm w x 103cm d)                                                                       Weight: 1950 kg (4290 lbs)

X-RAD SmART Mini:       
76.5”h x 43”w x 41”d (196cm h x 110cm w x 103cm d)                                                                       Weight: 1700 kg (3740 lbs)

X-RAD SmART Plus:        
76.5”h x 66”w x 41”d (196cm h x 170cm w x 103cm d)                                                                       Weight: 2300 kg (5060 lbs)

Electrical requirements

1N PE 230 V 50/60Hz 35 A or 3N PE 400 / 230 V 50/60Hz 25A (TN-S or TN-C-S)


Complies with US and European norms for radiation emission limits outside the cabinet 
Complies with US FDA regulation 21 CFR 1020.40 entitled “Cabinet X-ray Systems”

Related Options & Accessories

Available Options: